What’s Closed In Tier 4 Covid Lockdown? Record Of Shops And Companies Forced To Shut Underneath New Rules
The plasticity of immune cells and the balance between pro-inflammatory and anti inflammatory alerts are crucial elements of efficient tissue restore. Immune elements and pathways are involved in regeneration as properly, for instance in amphibians.
Individual plant cells reply to molecules associated with pathogens known as pathogen-associated molecular patterns or PAMPs. When a part of a plant becomes contaminated, the plant produces a localized hypersensitive response, whereby cells on the website of an infection bear fast apoptosis to stop the unfold of the disease to other parts of the plant. Systemic acquired resistance is a sort of defensive response utilized by vegetation that renders the entire plant resistant to a specific infectious agent.
Thenational restriction guidancehas been up to date with some additional data and clarifications. Please see some areas that may be of curiosity to tourism companies. Advice for UK visa applicants and momentary UK residentshas been updatedto clarify that overseas providers and in-country immigration services will stay open, however depending on local country restrictions. Also, the interval for requesting exceptional assurance has been extended when making use of to enter the UK or stay on the idea of family or personal life. Restaurants and bars within visitor accommodation should remain closed though meals and/or drink including alcohol can be supplied by way of room service as long as it’s ordered by cellphone or on-line. Communal spaces such as lounges or lobbies might remain open to friends however no food or drink must be served in these spaces, folks ought to be encouraged to not gather and social distancing should be noticed. Should not intentionally facilitate bookings that don’t adhere to government restrictions.
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One class of non-self molecules are known as antigens and are defined as substances that bind to specific immune receptors and elicit an immune response. The immune system protects its host from infection with layered defenses of increasing specificity. Physical obstacles forestall pathogens similar to bacteria and viruses from entering the organism. If a pathogen breaches these limitations, the innate immune system supplies an instantaneous, but non-particular response.
In the meantime guidance on the restrictions that shall be applicable in each tier has been revealed. The Christmas Support Payment is for wet-led pubs that have been severely impacted over the festive season as a result of momentary local restrictions.
The different cells concerned within the innate response include innate lymphoid cells, mast cells, eosinophils, basophils, and natural killer cells. A scanning electron microscope image of normal circulating human blood. One can see red blood cells, several knobby white blood cells together with lymphocytes, a monocyte, a neutrophil, and plenty of small disc-shaped platelets. Microorganisms or toxins that efficiently enter an organism encounter the cells and mechanisms of the innate immune system.
Tesco have been criticised for aggressively pursuing critics of the company in Thailand. Writer and former MP Jit Siratranont faced up to two years in jail and a £16.four million libel damages claim for saying that Tesco was expanding aggressively on the expense of small native retailers. Tesco served him with writs for criminal defamation and civil libel. The Thai court docket dismissed the case, ruling that the criticism made by the defendant was ‘in good faith by the use of truthful touch upon any person or thing subjected to public criticism’. According to Citigroup retail analyst David McCarthy, ” pulled off a trick that I’m not aware of another retailer achieving. That is to appeal to all segments of the market”. support firm called The PC Guys in 2007, and were capable of launch Tesco Tech Support in December 2008. It was introduced in March 2017 that Trevor Masters, International Chief Executive, would be leaving in May after 38 years with the company.
Something else to pay attention to is that each firm delivers to different parts of Essex and surrounding areas, together with North East London, so verify your location is covered to keep away from disappointment. Some companies could deliver outdoors their traditional delivery space when you’re preprepared to pay a supply surcharge, make a big order or in the event that they’ve received drivers out there, so it’s all the time value phoning to verify, even if you’re outdoors their said protection space. mySociety is a registered charity in England and Wales and a restricted firm .
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Kennards – Opened by Debenhams as a department of Kennards of Croydon; renamed Debenhams 1973. Re-opened because the Houndsditch earlier than closing in 1984 and being demolished and changed by Aylesham Centre. Howards – Bought by United Drapery Stores; later integrated into the John Blundell group; renamed John Blundell. George Hitchcock Williams & Co. (St Paul’s Churchyard, London) – Established 1841; closed 1984. Main buildings demolished and site redeveloped as Orchards Shopping Centre. Havens Opened 1901; Store closed in 2017 and moved to being a web-based retailer only. George Henry Havelock – Destroyed by fireplace 18 July 1898; rebuilt 1900; closed 1914.
This eveningPrime Minister, Boris Johnson gave a briefingon the latest COVID-19 measures. During his statement the Prime Minister introduced thatGreater Manchester will transfer to the ‘Very High’ local alert levelfrom midnight on Thursday 22 October. Liverpool City Region’s tier-three restrictionswill be up to date to align with those in Lancashire from Friday 23 October 2020. This implies that gyms will be allowed to reopen and gentle play areas will shut. People ought to purpose to reduce the number of journeys they make where attainable; if they need to journey, they should stroll or cycle the place potential, or plan forward and keep away from busy occasions and routes on public transport. People must not meet in a bunch of greater than 6 exterior, including in a backyard or different area.
The Government has announced the resumption of the easement of restrictions from 15 August. Some of remaining aspects of England’s culture, sport, leisure and enterprise sectors will be permitted to reopen from Saturday in England – except for specific areas the place local restrictions are in place – as follows.
The grant is for companies that pay business rates on their premises. Local councils could at their discretion additionally present funding for businesses that don’t pay enterprise rates. The Job Support Scheme might be expanded to help businesses throughout the UK who are legally required to shut their premises because of local or national coronavirus restrictions. Cafes and occasional shops are handled as restricted businesses for the purposes of the brand new native alert stage rules (the identical as restaurants, bars & pubs and so on). The expanded Job Support Scheme offers temporary support to companies whose premises have been legally required to close as a direct result of Coronavirus restrictions set by a number of of the four governments of the UK.
The increase in e-cigarette use, notably among young people, is a harmful pattern with real health dangers. For many reasons, e-cigarettes shouldn’t be promoted as a protected various to smoking.
If a resort has totally different venues inside it, similar to a restaurant or bar, separate QR code posters must be displayed in every of these. Guests can check into these areas allowing them to be sent notifications with public well being advice if wanted. Customers eating and ingesting within the outdoor setting shouldn’t collect in teams of more than 6 people. Where there isn’t a seating obtainable, the stall or outlet might be providing a take away service.
Offensive elements of the immune techniques are additionally present in unicellular eukaryotes, however research of their roles in protection are few. Claims made by entrepreneurs of varied products and different well being providers, similar to chiropractors, homeopaths, and acupuncturists to have the ability to stimulate or “enhance” the immune system typically lack meaningful rationalization and proof of effectiveness. The immune response could be manipulated to suppress undesirable responses resulting from autoimmunity, allergy, and transplant rejection, and to stimulate protective responses in opposition to pathogens that largely elude the immune system or most cancers. Inflammation is among the first responses of the immune system to infection, however it could appear with out recognized trigger. During wake intervals, differentiated effector cells, such as cytotoxic pure killer cells and cytotoxic T lymphocytes, peak to elicit an efficient response against any intruding pathogens.
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The profit overstatement was subsequently revised upwards to £263 million following an investigation by the accountancy firm Deloitte, and it was clarified that the inflated profit figure was the result of Tesco bringing forward rebates from suppliers. The Serious Fraud Office confirmed on 29 October 2014 that it was carrying out a criminal investigation into the accounting irregularities but declined to give additional particulars. Three executives charged with fraud and false accounting in connection with the misreporting had been cleared of the costs in 2018–2019. Euphorium Bakery opened a concession in Tesco’s Kensington store in 2012, and in 2013 Tesco bought a stake in the business. In August 2016, Tesco sold Euphorium’s high road retailers and factory in Islington to Soho Coffee, and its manufacturing facility in Weybridge to Samworth Brothers. In 2012, Tesco invested in a brand new coffee shop chain, named Harris + Hoole after espresso-loving characters in Samuel Pepys’ diary.
Weddingsandfuneralscan go forward with restrictions on the number of attendees – 15 individuals can attend marriage ceremony ceremonies, marriage ceremony receptions are not allowed, 30 people can attend funeral ceremonies, 15 folks can attend linked commemorative occasions. Weddings and funerals can go forward with restrictions on numbers of attendees – 15 folks can attend wedding ceremony ceremonies and receptions, 30 individuals can attend funeral ceremonies, and 15 folks can attend linked commemorative events. This afternoonPrime Minister Boris Johnson gave a statementto the House of Commons on theGovernment’s COVID-19 Winter Plan. The Prime Minister confirmed that the nationwide restrictions in England will finish on 2 December and that the country will transfer again into a regional tiered strategy. On Thursday 26 November the government is due to announce which areas are by which tier.
- The co-operative continues to function a variety of companies outdoors of non-food retail.
- Phagocytes generally patrol the physique looking for pathogens, but could be referred to as to specific areas by cytokines.
- Many corporations providing on-demand alcohol open within the night, right by way of to the early hours of the following morning.
- If the lodging supplier agrees, visitors might extend their stay so as to self-isolate till they are well enough to journey.
The new NHS COVID-19 app is now out there to download free of charge in England and Wales and is the fastest method to see should you or your business are in danger from coronavirus. TheSelf-Employment Income Support Schemevideo steering has been updated with info on tips on how to declare the second grant. We have acquired several queries from trade round particulars within the steerage, please see under some clarifications DCMS has shared with us you might find helpful. From midnight on 30 September, measures shall be brought into legislation proscribing inter-family mixing in indoor settings, including pubs and restaurants, in Durham, Gateshead, Newcastle, North Tyneside, South Tyneside, Northumberland and Sunderland. New restrictions have come into pressure in Leeds, Blackpool, Wigan and Stockport.
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Weddings, receptions, funerals, and commemorative occasions together with wakes can proceed with up to 30 attendees. Controlled indoor occasions of as much as 1,000 folks or 50% of a venue’s capacity, whichever is lower, will be permitted, as will outside events with a capability of either 50% or 4,000 folks, whichever is decrease. Some giant occasions, together with conferences, theatre and concert performances and sports occasions. People might be allowed to spend time in out of doors public spaces for recreation on their own, with one different individual, or with their household or support bubble. People should continue to keep up social distance from these outside their household. This is in addition to outside train which is already permitted.
Acquired by House of Fraser 1969; renamed Dingles 1973; renamed House of Fraser 2000s.Brights – Opened within the former premises of Bobby & Co. as a branch of Brights 1932. Subsequently, acquired by House of Fraser 1969; renamed Dingles 1973; closed Nineteen Nineties.
Cash assist for food redistribution through the coronavirus outbreak to stop meals waste. A new Coronavirus Large Business Interruption Loan Scheme will present a authorities guarantee of 80% to enable banks to make loans of as much as £25 million to corporations with an annual turnover of between £forty five million and £500 million. Updated steerage on the COVID-19 Statutory Sick Pay Rebate Scheme has been made out there. This scheme allows small and medium-sized employers, with fewer than 250 workers, to apply to HMRC to get well ivg eliquid blackcurrant millions 10ml 12mg the costs of paying Statutory Sick Pay to their staff. HMRC has published new online guidance which includes information about who can use the scheme and the data employers should hold. Read extra about the eligibility extensionandhow to assert assist by way of the scheme right here. Raab acknowledged that people had been keen for dates and plans, but said it was too soon to gauge the evidence.
People must not socialise with anyone they don’t reside with, or have shaped a support bubble with, in any indoor setting or in any non-public backyard or at most outdoor hospitality venues and ticketed occasions. Lancashirewill move from local COVID alert level high to very high on Saturday 17 October. The local COVID alert stage very excessive will take effect throughout all parts of Lancashire together with, Burnley, Blackburn with Darwen, Blackpool, Chorley, Fylde, Hyndburn, Lancaster, Pendle, Preston, Ribble Valley, Rossendale, South Ribble, West Lancashire, Wyre. Greater Manchester will receive £22 million of funding, along with funding already offered to local authorities in England to support them. South Yorkshirewill transfer from native COVID alert degree excessive to very high.
These cells have no cytotoxic activity and do not kill contaminated cells or clear pathogens instantly. They as a substitute management the immune response by directing different cells to carry out these duties. The cells of the adaptive immune system are particular types of leukocytes, known as lymphocytes. B cells and T cells are the main types of lymphocytes and are derived from hematopoietic stem cells in the bone marrow. B cells are involved in the humoral immune response, whereas T cells are concerned in cell-mediated immune response. Killer T cells only acknowledge antigens coupled to Class I MHC molecules, whereas helper T cells and regulatory T cells only recognize antigens coupled to Class II MHC molecules. These two mechanisms of antigen presentation mirror the different roles of the 2 forms of T cell.
See the guidance and restrictions for areas where the Local COVID Alert stage is Very High. People ought to attempt to keep away from travelling outdoors the ‘Very High’ space they’re in, or getting into a ‘Very High’ space, apart from for things like work, education, accessing youth providers, to fulfill caring responsibilities or if they’re in transit. See the steering and restrictions for areas the place the Local COVID Alert stage is High. Most areas which are already topic to native restrictions will automatically transfer into the “excessive” alert stage. As a result of rising an infection ratesNottinghamshire, East and West Cheshireand asmall space of High Peakwill also transfer into the “high” alert level.
The G20 Tourism Ministers held a meeting on COVID-19 on Friday 24 April, Tourism Minister Nigel Huddleston was in attendance and addressed the group. He spoke of the significance of tourism to the UK economic system, the Government’s assist measures and the regular discussions he’s in with the tourism industry about what their priorities are for the restoration interval. He highlighted the key areas of concern including how businesses can operate whereas there are nonetheless social distancing measures in place; what additional steerage is needed; and whether or not there is a want for tapered assist as companies adjust. The two metre social distancing rule shall be relaxed to at least one metre plus. Where it’s possible to remain two metres you need to proceed to do so, but where this is not attainable it ought to be a ‘one metre plus’ policy.
Key reductions included over a quarter of its staff in Welwyn Garden City and Hatfield, and the closure of the call centre in Cardiff. The firm began to increase the range of products it bought through the 1960s to incorporate household items and clothing under the Delamare model, and in 1974 opened its first petrol station. On 21 March 1997, Tesco introduced the purchase of the retail arm of Associated British Foods, which consisted of the Quinnsworth, Stewarts and Crazy Prices chains in Ireland and Northern Ireland, and associated companies, for £640 million. The deal was accredited by the European Commission on 6 May 1997. Tesco has expanded globally for the reason that early 1990s, with operations in eleven different countries on the planet. The company pulled out of the US in 2013, but as of 2018 continues to see development elsewhere.
No retailers are permitted to sell alcohol within the area and there are no pubs, bars or fast-food retailers in Bournville as a result of its Quaker roots. In June 2008, the government announced that it was closing a tax loophole being used by Tesco.
Eldred Sayers & Sons – Bought by Bentalls; renamed Bentalls; relocated. Rankin & Co. – Bought by Benzie & Miller; renamed Benzie & Miller. Acquired by House of Fraser 1958; renamed Arnotts Seventies; closed Nineteen Eighties. Acquired by House of Fraser 1975; renamed Chiesmans 1975; renamed Army & Navy; closed Nineteen Nineties. Nicholsons (Bromley; previously St Paul’s Churchyard, London) – Bought by Debenhams; St Paul’s Churchyard buildings destroyed by bombing; relocated to former cinema constructing in Bromley; renamed Debenhams 1973; closed 1990s.
His business expanded quickly, and by 1939 he had over 100 Tesco retailers throughout the country. Woolland Brothers – Established 1869; new building accomplished 1901. Woodard’s Opened 1908 on nook of Regent Street and the Parade. Store was closed by then house owners Merchant Retail on the 31st July 2004, contributing £300,000 revenue to the group.
Ribonucleases and the RNA interference pathway are conserved throughout all eukaryotes, and are thought to play a task in the immune response to viruses. Some tumors evade the immune system and go on to turn into cancers. Tumor cells usually have a reduced number of MHC class I molecules on their floor, thus avoiding detection by killer T cells. Some tumor cells also release merchandise that inhibit the immune response; for example by secreting the cytokine TGF-β, which suppresses the activity of macrophages and lymphocytes. In addition, immunological tolerance might develop towards tumor antigens, so the immune system now not assaults the tumor cells. The major response of the immune system to tumors is to destroy the irregular cells using killer T cells, generally with the help of helper T cells.
Pearsons was offered to Morleys Stores in 2010, with the Bishop Stortford retailer closed in 2012. Lincolnshire Co-operative – operated a variety of malls, the remaining two of which, in Lincoln and Gainsborough, have been acquired by Oldrids in 2013. The co-operative continues to operate a variety of companies outside of non-food retail. Unlike animals, vegetation lack phagocytic cells, however many plant immune responses involve systemic chemical signals which might be sent via a plant.
New steering might be printed to support companies – together with changing office layouts, protecting screens, closing non-essential communal areas etc. Guidance on closing sure companies and venues in England has been up to date following the additional easing of coronavirus restrictions from 4 July, as well as location-particular guidance for closing companies in Leicester.
We present industrial services via our wholly owned subsidiary SocietyWorks Ltd . In March 2015 an arson attack gutted a new Tesco Express shop in Godalming, Surrey, two days earlier than it was due to open. Tesco had purchased a public home and converted it to the new store, a change which did not require planning permission, thus denying the vigorous local opposition any formal means of stopping it. After continuing local opposition, together with the local MP and borough council, Tesco abandoned its plans for the store in January 2017. Tesco made a commitment to company social accountability in the type of contributions of 1.87% in 2006 of its pre-tax profits to charities and local people organisations.
Subsequently, acquired by House of Fraser 1972; renamed Binns; closed c. Acquired by House of Fraser 1957; closed 1968; reopened as Dickins & Jones on completion of new constructing 1970; renamed House of Fraser 2007. Acquired by House of Fraser 1976; renamed Dingles; closed Eighties. Gamis’s – established in 1828 by Ince Gamis as ‘perfumer, hairdresser and toy vendor’ and traded successively as Ince Gamis, Gamis & Hunt, Gamis & Co. and Gamis’s. The enterprise got here to be owned by House of Fraser within the Seventies (probably through a larger acquisition?) and was renamed Dingles before closing within the 1980s. John Falconer & Co. – Bought by Scottish Drapery Corporation 1929. Acquired by House of Fraser 1952; renamed Frasers Seventies; closed 2002.
Neutrophils are usually discovered in the bloodstream and are essentially the most abundant kind of phagocyte, representing 50% to 60% of complete circulating leukocytes. During the acute section of inflammation, neutrophils migrate towards the positioning of inflammation in a process known as chemotaxis, and are often the first cells to arrive on the scene of infection. The info on this web page contains common information about the Government’s COVID-19 steering and laws, as relevant to companies, and has been supplied in good faith. eleven March – In the2020 finances, the UK Government announced assist for businesses affected by COVID-19. 22 March – The Government has introduced the launch of the business assist measures outlined final week. As a part of this, they have additionally launched a devoted business web site that collates information on the assist out there for businesses. Updated information on the closing sure companies and venues page around compliance.
Updated guidanceis available to help employers calculate workers’ working and furloughed hours for staff who came off furlough partway by way of a declare interval. Employers utilizing this calculation don’t have to amend previous claims. Reviewwhat individuals can and can’t do, and note that places impacted bylocal lockdown measuresmay be topic to different rules. Following the launch of the new COVID-19 app, prospects and guests in England will have the ability to examine-in on entry with their cellphone instead of filling out a check-in book or device specific to a enterprise. This will allow NHS Test and Trace to contact customers with public well being advice ought to there be a COVID-19 outbreak. Businesses who’re already using their own QR system are being encouraged to modify to the NHS Test and Trace QR code.
Attwoods – purchased by Kay & Co. of Worcester, the catalogue business within the Nineteen Fifties. Fear Hill – group of four department stores; the Trowbridge retailer was established in 1880. Allders Department Stores – group went into administration on 29 January 2005. The flagship Croydon store continued to trade independently after 2005, lastly closing on 22 September 2012. In the case of department store groups, the placement of the flagship store is given. This list doesn’t embrace large specialist shops, which generally resemble malls.
Leicester-particular steering for social distancing throughout a neighborhood lockdown has also been updated. Business conferences and occasions of over 30 folks should not currently take place in conference centres and exhibition halls.
Weddings and civil partnership ceremonieswill not be permitted to happen besides the place a kind of getting married is critically sick and never anticipated to recover (‘deathbed wedding’). A newgraphical posterdisplaying details about the national restrictions in England is out there to download. Are at present in that lodging at the time when national restrictions come into pressure. Roofed historic buildings and totally-enclosed areas will be closed, though their hooked up grounds, including automobile parks, bogs and out of doors play areas, can remain open.
By Smok Tfv12 Coils 3 Pack T14 , the number of Homeplus retailers within the United Kingdom had reached 12; the latest shop opened in Chester in July 2009. In 2012 it was reported that Tesco was seeking to shut the business to focus on groceries. Tesco closed six Homeplus outlets on 15 March 2015, and the remaining six retailers closed on 27 June 2015. Hurst & Sandler – principally a producer of gowns and other textile items. The firm owned numerous subsidiary wholesale and retail drapery companies in Yorkshire, together with Willis Brothers of Hull and Ludlows of Bradford , John Banner of Sheffield, Lingards of Bradford and Rushworths of Huddersfield. Neutrophils and macrophages are phagocytes that journey throughout the physique in pursuit of invading pathogens.
A third, minor subtype are the γδ T cells that acknowledge intact antigens that are not sure to MHC receptors. The double-positive T cells are exposed to all kinds of self-antigens within the thymus, by which iodine is important for its thymus growth and activity. In distinction, the B cell antigen-particular receptor is an antibody molecule on the B cell surface and acknowledges native antigen with none want for antigen processing. Such antigens may be massive molecules discovered on the surfaces of pathogens, however may also be small haptens attached to provider molecule. Each lineage of B cell expresses a different antibody, so the complete set of B cell antigen receptors characterize all the antibodies that the physique can manufacture. When B or T cells encounter their related antigens they multiply and many “clones” of the cells are produced that target the same antigen.
Bacteria typically overcome bodily barriers by secreting enzymes that digest the barrier, for example, by utilizing a kind II secretion system. Alternatively, using a type III secretion system, they may insert a hole tube into the host cell, providing a direct route for proteins to maneuver from the pathogen to the host. Evolution of the adaptive immune system occurred in an ancestor of the jawed vertebrates. Many of the classical molecules of the adaptive immune system (for instance, immunoglobulins and T-cell receptors) exist only in jawed vertebrates. A distinct lymphocyte-derived molecule has been found in primitive jawless vertebrates, such because the lamprey and hagfish.
Type IV reactions are involved in many autoimmune and infectious illnesses, however can also involve contact dermatitis. These reactions are mediated by T cells, monocytes, and macrophages. Overactive immune responses kind the opposite finish of immune dysfunction, significantly the autoimmune issues. Here, the immune system fails to correctly distinguish between self and non-self, and assaults part of the body. Under normal circumstances, many T cells and antibodies react with “self” peptides. One of the features of specialised cells is to present younger lymphocytes with self antigens produced throughout the physique and to eliminate these cells that recognize self-antigens, preventing autoimmunity. Common autoimmune ailments include Hashimoto’s thyroiditis, rheumatoid arthritis, diabetes mellitus kind 1, and systemic lupus erythematosus.
Closing sure businesses and venues in England steering has been up to date to indicate further easing of restrictions for more companies and venues to reopen from 25 July and 1 August. Public Health England has revealed the Customer Logging Toolkit. This incorporates a variety of template materials for businesses to show, in addition to guidance on how the coverage works. Businesses ought to be storing the data securely for 21 days and sharing it with NHS Test and Trace if requested to do so. Businesses do not need to do anything else with the data.
The record of indoor sports and leisure centres has been updated to incorporate gyms. People can proceed to journey to venues or facilities which are open, however ought to goal to reduce the variety of journeys they make the place a guide on 13 popular vaping tricks potential. Organised indoor sport, bodily activity and train classes cannot happen indoors. Large out of doors occasions shouldn’t happen, excluding drive-in occasions.
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Elena is an avid blogger who enjoys writing articles on fashion, beauty, lifestyle, fitness and recently, CBD niches. Elena has been described as a "delightfully eccentric with a creative take on things" (New York Times) with an ability to "bring you new facts that will make you go WOW!" (Vanity Fair). Elena has been writing since her uni days where she was a regular contributor to the student magazine. After pursuing a career in finance in the heart of London's financial hub, Elena has decided to start blogging in her spare time as an outlet for her creativity and ideas. During her spare time, Elena enjoy horse riding, camping and hiking, interior design and keeping abreast with the latest trends. Elena is in the process of starting up her own beauty cosmetics line in the near future. Elena is also a contributing author to fashion and lifestyle magazines and has been featured in Vice, Country Living, Harrods magazine, Daily Telegraph, Grazia and Women's Health.